Scientific Research and Experimental Development (SR&ED) and the Industrial Research Assistance Program (IRAP) are two of the largest government incentive programs in Canada.  The chart below details some of the major differences between the 2 programs.

Criteria Scientific Research and Experimental Development (SR&ED) Industrial Research Assistance Program (IRAP)
Administration SR&ED is administered by the Canada Revenue Agency (CRA) IRAP is administered by the National Research Council (NRC)
Type of program SR&ED is a tax credit for eligible R&D expenditures incurred as per the federal Income Tax Act IRAP is a government grant program
Governance Financial and technical reviews administered by the CRA, after application Upon approval, the NRC requires regular reporting of progress when compared to deliverables
Amount Up to 35% as a refundable tax credit (federal), plus provincial tax credits.  20% non-refundable tax credit for foreign-owned or public corporations IRAP non-repayable grants vary from $15,000 to $1 million
Application Process Submit technical narratives and T661 [Scientific Research and Experimental Development (SR&ED) Expenditures Claim] with tax returns or amended tax returns Contact Industrial Technology Advisor for consultation.  An IRAP application requires a financial business plan and technology plan